ECG-based parameters combined exosomes in atrial fibrillation: Diagnosis potential and role as clinical biomarkers

We have greatly enjoyed reading the published article by Evert P M Karregat and colleagues [1]. Electrocardiography are currently the gold standards for AF diagnosis, but due to its short recording time window, paroxysmal atrial fibrillation goes undetected in many patients [2–4]. Therefore, it would be helpful to develop alternative convenient and efficient diagnostic tools. Excitingly, 9 ECG parameters were associated with AF detection (the presence of AVB, LVH, PAC, greater maximum PWD, PR-interval, P-wave dispersion, P-wave index, QTc interval, and shorter minimum P-wave duration) [4].